INTRODUCTION	ASSAYS	LINKS	CONTACT

Useful Links:

MEIC study results:

Overview of the Final MEIC Results: II. The In Vitro±In Vivo Evaluation, Including the Selection of a Practical Battery of Cell Tests for Prediction of Acute Lethal Blood Concentrations in Humans*

B. EKWALL

Toxicology in Vitro 13 (1999) 665±673

Overview of the Final MEIC Results: I. The In Vitro±In Vitro Evaluation

C. CLEMEDSON* and B. EKWALL

Toxicology in Vitro 13 (1999) 657±663

Other NanoToxicity Websites:

EHS safety information on Nanomaterials and toxicology at MIT
http://web.mit.edu/environment/ehs/topic/nanomaterial.html

Nanotoxicology Research at the University of Florida

http://www.nanotoxicology.ufl.edu/

Center for Biological and Environmental Nanotechnology, at the Rice University

http://cohesion.rice.edu/centersandinst/cben/research.cfm?doc_id=5101

National Cancer Institute Alliance for Nanotechnology in Cancer

http://nano.cancer.gov/

National Institute for Occupational Safety and Health

http://www.cdc.gov/niosh/topics/nanotech/

Nanotechnology Characterization Laboratory

http://ncl.cancer.gov/

California Nanosystems Institute

http://www.cnsi.ucla.edu/

Center for Integrated Nanotechnology

http://cint.lanl.gov/

Nanoscale science and engineer center

http://www.nsec.harvard.edu/index.htm

Selection of Nanotoxicology Papers:

Acute toxicological effects of copper nanoparticles in vivo

Zhen Chen, Huan Meng, Gengmei Xing, Chunying Chen, Yuliang Zhao, Guang Jia, Tiancheng Wang, Hui Yuan, Chang Ye, Feng Zhao, Zhifang Chai, Chuanfeng Zhu, Xiaohong Fang, Baocheng Ma, Lijun Wan

Toxicology Letters 163 (2006) 109–120

A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors

Ron Hardman

Environmental Health Perspectives , VOL 114, NUMBER 2 ,February 2006

Solid lipid nanoparticles of mitoxantrone for local injection against breast cancer and its lymph node metastases

Bin Lu, Su-Bin Xiong, Hong Yang, Xiao-Dong Yin, Ruo-Bing Chao

European journal of pharmaceutical sciences (2006)

Multi-walled carbon nanotubes induce T lymphocyte apoptosis

Massimo Bottini, Shane Bruckner, Konstantina Nika, Nunzio Bottini, Stefano Bellucci, Andrea Magrini, Antonio Bergamaschi, Tomas Mustelin.

Toxicology Letters 160 (2006) 121–126

Self-assembled drug delivery systems 1. Properties and in vitro/in vivo behavior of acyclovir self-assembled nanoparticles (SAN)

Yiguang Jin, Li Tong, Ping Ai, Miao Li, Xinpu Hou

International Journal of Pharmaceutics 309 (2006) 199–207

Research Strategies for Safety Evaluation of Nanomaterials, Part IV: Risk Assessment of Nanoparticles

Joyce S. Tsuji, Andrew D. Maynard, Paul C. Howard, John T. James, Chiu-wing Lam, David B. Warheit and Annette B. Santamaria

Toxicol Sci. 2006 Jan; 89(1):42-50

Toxic Potential of Materials at the Nanolevel

Andre Nel, Tian Xia, Lutz Madler, Ning Li

SCIENCE 3 FEBRUARY 2006 VOL 311

Cerium and yttrium oxide nanoparticles are neuroprotective

David Schubert, Richard Dargusch, Joan Raitano, Siu-Wai Chan

Biochemical and Biophysical Research Communications 342 (2006) 86–91

Evaluation of the microbial growth response to inorganic nanoparticles

Darryl N Williams, Sheryl H Ehrman, Tracey R Pulliam Holoman

Journal of Nanobiotechnology 2006, 4:3

Toxicity and Tissue Distribution of Magnetic Nanoparticles in Mice

Jun Sung Kim, Tae-Jong Yoon, Kyeong Nam Yu, Byung Gul Kim, Sung Jin Park, Hyun Woo Kim, Kee Ho Lee, Seung Bum Park, Jin-Kyu Lee and Myung Haing Cho

Toxicological Sciences 2006 89(1):338-347

Pulmonary Instillation Studies with Nanoscale TiO2 Rods and Dots in Rats: Toxicity is not Dependent Upon Particle Size and Surface Area

DB Warheit, TR Webb, CM Sayes, VL Colvin, and KL Reed

Toxicol Sci. 2006 Feb 22

Carbon Nanotubes: a Review of Their Properties in Relation to Pulmonary Toxicology and Workplace Safety

Ken Donaldson, Robert Aitken, Lang Tran, Vicki Stone, Rodger Duffin, Gavin Forrest, and Andrew Alexander

Toxicol Sci. 2006 Feb 16

Environmental Risks of Nanotechnology: National Nanotechnology Initiative Funding, 2000-2004

KATHERINE A. DUNPHY GUZMAN, MARGARET R. TAYLOR, AND JILLIAN F. BANFIELD

Environ. Sci. Technol.2006, 40,1401-1407

Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro

Christie M. Sayes, Feng Liang, Jared L. Hudson, Joe Mendez, Wenhua Guo, Jonathan M. Beach, Valerie C. Moore, Condell D. Doyle, Jennifer L. West, W. Edward Billups, Kevin D. Ausman, Vicki L. Colvin

Toxicology Letters 161 (2006) 135–142

Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers

Ravi Singh, Davide Pantarotto, Lara Lacerda, Giorgia Pastorin, Ce´ dric Klumpp, Maurizio Prato Alberto Bianco, and Kostas Kostarelos

PNAS February 28, 2006, vol. 103 no. 9 3357–3362

Mechanisms Underlying Nano-Sized Air-Pollution -Mediated Progression of Atherosclerosis Carbon Black Causes Cytotoxic Injury/Inflammation and Inhibits Cell Growth in Vascular Endothelial Cells

Hideyuki Yamawaki, PhD; Naoharu Iwai, MD

Circ J 2006; 70: 129 – 140

An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles

ODED RABIN, J. MANUEL PEREZ, JAN GRIMM, GREGORY WOJTKIEWICZ AND RALPH WEISSLEDER

Nat Mater. 2006 Feb;5(2):118-22. Epub 2006 Jan 29.

Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: Role of iron

V.E. Kagan, Y.Y. Tyurin, V.A. Tyurin, N.V. Konduru, A.I. Potapovich, A.N. Osipov, E.R. Kisin, D. Schwegler-Berry, R. Mercer, V. Castranova , A.A. Shvedova

Toxicology Letters (2006)

Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure

Ken Donaldson, Lang Tran, Luis Albert Jimenez, Rodger Duffin, David E Newby, Nicholas Mills, William MacNee and Vicki Stone

Particle and Fibre Toxicology 2005, 2:10

Smaller is not always better: nanotechnology yields nanotoxicology

Howard M. Kipen and Debra L. Laskin

289:696-697, 2005. AJP – Lung

Relative Risk Analysis of Several Manufactured Nanomaterials: An Insurance Industry Context

CHRISTINE OGILVIER OBICHAUD, DICK SENTANZIL, ULRICH WEILENMANN, AND MARK R. WIESNER

Environ. Sci. Technol.2005, 39,8985-8994

Bacterial cell association and antimicrobial activity of a C60 water suspension.

Lyon DY, Fortner JD, Sayes CM, Colvin VL, Hughe JB.

Environ Toxicol Chem. 2005 Nov;24(11):2757-62

Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles

Günter Oberdörster, Eva Oberdörster and Jan Oberdörster

Environmental Health Perspectives Volume 113, Number 7, July 2005

Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy

Günter Oberdörster, Andrew Maynard, Ken Donaldson, Vincent Castranova, Julie Fitzpatrick, Kevin Ausman, Janet Carter, Barbara Karn, Wolfgang Kreyling, David Lai, Stephen Olin, Nancy Monteiro-Riviere, David Warheit, Hong Yang and a report from the ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group

Particle and Fibre Toxicology 2005, 2:8

In vitro toxicity of nanoparticles in BRL 3A rat liver cells

S.M. Hussain a, K.L. Hess, J.M.Gearhart, K.T. Geiss, J.J. Schlager

Toxicology in Vitro 19 (2005) 975–983

The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle.

Mei Z, Li X, Wu Q, Hu S, Yang X.

Pharmacol Res. 2005 Apr;51(4):345-51

Nano-C60 cytotoxicity is due to lipid peroxidation

Christie M. Sayes, Andre M. Gobin, Kevin D. Ausman, Joe Mendez, Jennifer L. West, Vicki L. Colvin

Biomaterials 26 (2005) 7587–7595

Research Strategies for Safety Evaluation of Nanomaterials, Part I: Evaluating the Human Health Implications of Exposure to Nanoscale Materials

Karluss Thomas and Philip Sayre

Toxicol Sci. 2005 Oct;87(2):316-21

Silver/Dendrimer Nanocomposites as Biomarkers: Fabrication, Characterization, in Vitro Toxicity, and Intracellular Detection

Wojciech Lesniak, Anna U. Bielinska, Kai Sun, Katarzyna W. Janczak, Xiangyang Shi, James R. Baker Jr. and Lajos P. Balogh

Nano Lett., Vol. 5, No. 11, (2005 ):2123-30.

Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots

Jasmina Lovriæ. Hassan S. Bazzi. Yan Cuie. Genevieve R. A. Fortin. Françoise M. Winnik. Dusica Maysinger

J Mol Med (2005) 83: 377–385

Imaging, distribution, and toxicity of superparamagnetic iron oxide magnetic resonance nanoparticles in the rat brain and intracerebral tumor.

Muldoon LL, Sandor M, Pinkston KE, Neuwelt EA.

Neurosurgery. 2005 Oct; 57(4):785-96

Research Strategies for Safety Evaluation of Nanomaterials, Part II: Toxicological and Safety Evaluation of Nanomaterials, Current Challenges and Data Needs

Michael P. Holsapple, William H. Farland, Timothy D. Landry, Nancy A. Monteiro-Riviere, Janet M. Carter, Nigel J. Walker and Karluss V. Thomas.

Toxicol Sci. 2005 Nov;88(1):12-7

Multihydroxylated [Gd@C82(OH)22] n Nanoparticles: Antineoplastic Activity of High Efficiency and Low Toxicity

Chunying Chen, Gengmei Xing, Jiangxue Wang, Yuliang Zhao, Bai Li, Jun Tang, Guang Jia, Tiancheng Wang, Jin Sun, Li Xing, .Hui Yuan, Yuxi Gao, Huan Meng, .Zhen Chen, .Feng Zhao, Zhifang Chai and Xiaohong Fang

Nano Lett., Vol. 5, No. 10, (2005): 2050-7

Preparation and Evaluation of Thiol-Modified Gelatin Nanoparticles for Intracellular DNA Delivery in Response to Glutathione

Sushma Kommareddy and Mansoor Amiji

Bioconjugate Chem. 2005, 16, 1423-1432

Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles

Günter Oberdörster, Eva Oberdörster and Jan Oberdörster

Environ Health Perspect. 2005 Jul;113(7):823-39

Respiratory toxicity of multi-wall carbon nanotubes

Julie Muller, Francois Huaux, Nicolas Moreau, Pierre Misson, Jean-Francois Heilier, Monique Delos, Mohammed Arras, Antonio Fonseca, Janos B. Nagy, Dominique Lison

Toxicology and Applied Pharmacology 207 (2005) 221– 231

Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG–PEI

E. Kleemann, M. Neu, N. Jekel, L. Fink, T. Schmehl, T. Gessler, W. Seeger , T. Kissel

Journal of Controlled Release 109 (2005) 299–316

Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells

Jia-Ran Gurr, Alexander S.S. Wang, Chien-Hung Chenb, Kun-Yan Jan

Toxicology 213 (2005) 66–73

Single-Walled Carbon Nanotube Induces Oxidative Stress and Activates Nuclear Transcription Factor-KB in Human Keratinocytes

Sunil K. Manna, Shubhashish Sarkar, Johnny Barr, Kimberly Wise, Enrique V. Barrera, Olufisayo Jejelowo, Allison C. Rice-Ficht and Govindarajan T. Ramesh

Nano Lett. 2005 Sep;5(9):1676-84.

Indomethacin-loaded methoxy poly(ethylene glycol)/poly(D,L-lactide) amphiphilic diblock copolymeric nanospheres: Pharmacokinetic and toxicity studies in rodents

So Yeon Kim, Young Moo Lee, Ju Seop Kang

J Biomed Mater Res A. 2005 Sep 15;74(4):581-90

Calls Rise for More Research on Toxicology of Nanomaterials

ROBERT F. SERVICE

www.sciencemag.org SCIENCE VOL 310 9 DECEMBER 2005

[60]Fullerene is a Powerful Antioxidant in Vivo with No Acute or Subacute Toxicity

Najla Gharbi, Monique Pressac, Michelle Hadchouel, Henri Szwarc, Stephen R. Wilson and Fathi Moussa

Nano Lett., Vol. 5, No. 12, 2005

In Vitro Cytotoxicity of Nanoparticles in Mammalian Germline Stem Cells

Laura Braydich-Stolle, Saber Hussain, John J. Schlager and Marie-Claude Hofmann

Toxicol Sci. 2005 Dec;88(2):412-9

Particle surface characteristics may play an important role in phytotoxicity of alumina nanoparticles

Ling Yang , Daniel J. Watts

Toxicology Letters 158 (2005) 122–132

Effects of nano particles on antigen-related airway inflammation in mice

Ken-ichiro Inoue, Hirohisa Takano, Rie Yanagisawa, Miho Sakurai, Takamichi Ichinose, Kaori Sadakane and Toshikazu Yoshikawa

Respiratory Research 2005, 6:106

The effects of particle size and surface coating on the cytotoxicity of nickel ferrite

H. Yin, H.P. Too, G.M. Chow

Biomaterials 26 (2005) 5818–5826

Cytotoxicity of Carbon Nanomaterials: Single-Wall Nanotube, Multi-Wall Nanotube, and Fullerene

GUANG JIA, HAIFANG WANG, LEI YAN, XIANG WANG, RONGJUAN PEI, TAO YAN, YULIANG ZHAO, AND XINBIAO GUO

Environ Sci Technol. 2005 Mar 1;39(5):1378-83.

Bright Fluorescent Nanodiamonds: No Photobleaching and Low Cytotoxicity

Shu-Jung Yu, Ming-Wei Kang, Huan-Cheng Chang, Kuan-Ming Chen, and Yueh-Chung Yu

J. AM. CHEM. SOC. 2005, 127, 17604-17605

Manufactured Nanomaterials (Fullerenes, C60) Induce Oxidative Stress in the Brain of Juvenile Largemouth Bass

Eva Oberdörster

Environmental Health Perspectives , VOLUME 112, NUMBER 10, July 2004

Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation

Chiu-Wing Lam, John T. James, Richard McCluskey and Robert L. Hunter

TOXICOLOGICAL SCIENCES 77, 126–134 (2004)

On the Cyto-Toxicity Caused by Quantum Dots

Amane Shiohara, Akiyoshi Hoshino, Ken-ichi Hanaki, Kazuo Suzuki, and Kenji Yamamoto

Microbiol. Immunol., 48(9), 669-675, 2004

Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice

Anna A. Shvedova, Elena R. Kisin, Robert Mercer, Ashley R. Murray, Victor J. Johnson, Alla I. Potapovich, Yulia Y. Tyurina, Olga Gorelik, Sevaram Arepalli, Diane Schwegler-Berry, Ann F. Hubbs, James Antonini, Douglas E. Evans, Bon-Ki Ku, Dawn Ramsey, Andrew Maynard, Valerian E. Kagan, Vincent Castranova, and Paul Baron

Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708

Probing the Cytotoxicity of Semiconductor Quantum Dots

Austin M. Derfus, Warren C. W. Chan, and Sangeeta N. Bhatia

Nano Lett., Vol. 4, No. 1, 2004

Near-Infrared Fluorescence Microscopy of Single-Walled Carbon Nanotubes in Phagocytic Cells

Paul Cherukuri, Sergei M. Bachilo, Silvio H. Litovsky and R. Bruce Weisman

J. AM. CHEM. SOC. 2004, 126, 15638-15639

Cytotoxicity of anticancer drugs incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell line

L. Serpe, M.G. Catalano, R. Cavalli, E. Ugazio, O. Bosco, R. Canaparo, E. Muntoni, R. Frairia, M.R. Gasco, M. Eandi, G.P. Zara

European Journal of Pharmaceutics and Biopharmaceutics 58 (2004) 673–680

Toxicity of Gold Nanoparticles Functionalized with Cationic and Anionic Side Chains

Catherine M. Goodman, Catherine D. McCusker, Tuna Yilmaz, and Vincent M. Rotello

Bioconjugate Chem. 2004, 15, 897-900

Cytotoxicity studies of Dynasan 114 solid lipid nanoparticles (SLN) on RAW 264.7 macrophages—impact of phagocytosis on viability and cytokine production

Olbrich C., Schöler N., Tabatt K., Kayser O. Müller R.H.

Journal of Pharmacy and Pharmacology, Volume 56, Number 7, 1 July 2004, pp. 883-891(9)

Lipid-drug conjugate nanoparticles of the hydrophilic drug diminazene—cytotoxicity testing and mouse serum adsorption

Carsten Olbrich, Andrea Gessner, Werner Schroder, Oliver Kayser, Rainer H. MullerJournal of Controlled Release 96 (2004) 425– 435

Comparative Pulmonary Toxicity Assessment of Single-wall Carbon Nanotubes in Rats

D. B. Warheit, B. R. Laurence, K. L. Reed, D. H. Roach, G. A. M. Reynolds, and T. R. WebbTOXICOLOGICAL SCIENCES 77, 117–125 (2004)

Nanomaterials Show Signs of Toxicity

ROBERT F. SERVICE

SCIENCE VOL 300 11 APRIL 2003

Effect of lipid matrix and size of solid lipid nanoparticles (SLN) on the viability and cytokine production of macrophages

N. Scholer, H. Hahn, R.H. Muller, O. Liesenfeld

International Journal of Pharmaceutics 231 (2002) 167–176

Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma

S.E. Gelperina, A.S. Khalansky, I.N. Skidan, Z.S. Smirnova, A.I. Bobruskin, S.E. Severin, B. Turowski, F.E. Zanella, J. Kreuter

Toxicology Letters 126 (2002) 131–141

Study on the anticarcinogenic effect and acute toxicity of liver-targeting mitoxantrone Nanoparticles

ZHANG Zhi-Rong, HE Qin, LIAO Gong-Tie and BAI Shao-Huai

World J Gastroenterol.1999 Dec;5(6):511-514.